Promethazine HCl and Codeine Phosphate Oral Resolution is indicated for that non permanent aid of coughs and upper respiratory signs connected with allergy or the prevalent chilly in people eighteen yrs of age and older.
A potentially fatal symptom advanced from time to time called Neuroleptic Malignant Syndrome (NMS) has actually been claimed in Affiliation with promethazine HCl by itself or in combination with antipsychotic medication.
In animal replica scientific tests, codeine administered through the oral route to Expecting rats throughout the duration of organogenesis improved resorptions and reduced fetal weights in a dose approximately 25 instances the maximum encouraged human dose (MRHD) during the presence of maternal toxicity (see Facts).
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than six years of age, simply because The mix may possibly cause deadly respiratory melancholy Within this age population.
As a consequence of identical pharmacologic Homes, it really is affordable to anticipate similar danger with concomitant usage of opioid cough remedies and benzodiazepines, other CNS depressants, or alcohol.
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Resolution shouldn't be enhanced if cough fails to reply; an unresponsive cough need to be reevaluated in 5 days or sooner for attainable underlying pathology, like international human body or reduced respiratory tract ailment [see Dosage and Administration (two.three)].
Discontinuation of a concomitantly made use of cytochrome P450 2D6 inhibitor may well end in a lower get more info in codeine plasma focus and an increase in active metabolite morphine plasma focus which could improve or lengthen adverse reactions and could cause most likely deadly respiratory depression.
Press get more info release Codeine linctus to get reclassified to your prescription-only medication due to hazard of abuse and dependancy Men and Actavis promethazine codeine women are urged to hunt guidance from healthcare specialists whenever they really feel they are getting to be dependent on or addicted to codeine linctus. From:
Promethazine HCl and Codeine Phosphate Oral Remedy needs to be made use of with warning in individuals with severe impairment of renal function, and people need to be monitored carefully for respiratory melancholy, sedation, and hypotension.
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The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated, necessitating very more info careful thought of the effects to the parent drug, codeine, plus the active metabolite, morphine.
Narcotic analgesics might lead to nausea and vomiting by stimulating the chemoreceptor trigger zone (CTZ); even so, In addition they depress the vomiting center, to ensure subsequent doses are not likely to produce vomiting. Nausea is nominal just after typical oral doses of codeine.
Focus–Adverse Response Associations There's a connection in between growing codeine plasma concentration and raising frequency of dose- relevant opioid adverse reactions which include nausea, vomiting, CNS consequences, click here and respiratory depression.